
Certificate of Analysis · Click to view PDFN° 001Catalog Entry
TB-500
Thymosin β4 fragment (synthetic)
★★★★★Be the first to reviewActin-binding peptide studied in tissue repair
Independently tested
Janoshik Analytical · Oct 2025
- Purity (HPLC)
- 99.546%
- Measured
- 11.58 mg
- label 10 mg
- Tested batch
- Not stated
View the original report (PDF)How to verify itExact-lot documentation on request
Research-use-only catalog item supplied for laboratory identification and research purposes. Not for human consumption.
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Need supplies too? Add the TB-500 Starter Kitplus bacteriostatic water, syringes, and alcohol pads for just +$30View →Description
TB-500 is a synthetic peptide based on the active region of thymosin beta-4, a protein involved in cell structure and movement. It is used in laboratory work on cell migration, blood vessel formation and tissue repair models. Supplied as a lyophilized powder, strictly for laboratory research and analytical use.
Intended use · In-vitro laboratory research only. Not for human or animal consumption, and not for clinical, diagnostic, cosmetic or personal use.
N° 002 · How It Works
How TB-500 works.
TB-500 copies the part of thymosin beta-4 that binds actin, the protein cells use as internal scaffolding. By binding actin it affects how cells change shape and move, which is why it turns up in studies of cell migration. Research on thymosin beta-4 has looked at wound repair, the growth of new blood vessels, and heart tissue after injury. One thing worth being clear about: almost all of that work studies the full protein, not the shorter TB-500 sequence.
Studies referenced
- 1.Safer D, Elzinga M, Nachmias VT (1991). Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem. PubMed 1999398
- 2.Malinda KM, Sidhu GS, Mani H, et al. (1999). Thymosin beta4 accelerates wound healing. J Invest Dermatol. PubMed 10469335 · doi:10.1046/j.1523-1747.1999.00708.x
- 3.Bock-Marquette I, Saxena A, White MD, et al. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. PubMed 15565145 · doi:10.1038/nature03000
- 4.Goldstein AL, Hannappel E, Sosne G, et al. (2012). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. PubMed 22074294 · doi:10.1517/14712598.2012.634793
These are the studies behind the summary above. They describe laboratory, animal or clinical research, not this product.
N° 003 · Research Areas
What researchers study TB-500 for.
Areas where TB-500 shows up in published research. Listed for context only. We don't give dosing or human-use guidance.
- 01Wound healing models
- 02Heart and blood vessel repair studies
- 03Tendon, ligament and muscle repair
- 04New blood vessel growth (angiogenesis) assays
N° 004 · Specifications
Product specifications.
The molecular details for this compound.
Molecular Spec Sheet
Edition · 2026
- Catalog ID
- SP-TB500-10
- Purity
- 99.546% (HPLC)
- Molecular Weight
- ≈ 4 963 Da
- Sequence
- LKKTETQ (active core, full peptide is 43 residues)
- Sequence Note
- Synthetic fragment of human thymosin β4
- Storage
- 2 to 8°C, protect from light
- Intended Use
- Laboratory research only
N° 005 · Lab Handling
Reconstitution & storage notes.
- 01Reconstitute in sterile or bacteriostatic water for in-vitro reference work
- 02Aliquot reconstituted material and store at −20°C
- 03Lyophilized vial: 2 to 8°C, protect from light
All products are intended strictly for laboratory research use only. Not for human consumption. Not for medical, diagnostic, therapeutic, veterinary, or household use. Product information is provided for research identification and catalog purposes only.
N° 006 · Related
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