
Certificate of Analysis · Click to view PDFN° 001Catalog Entry
Retatrutide
RETA · GLP-3 · LY3437943
★★★★★5.0· 1 reviewTriple receptor agonist for metabolic research
Independently tested
Janoshik Analytical · Mar 2026
- Purity (HPLC)
- 99.705%
- Measured
- 10.71 mg
- label 10 mg
- Tested batch
- 01
View the original report (PDF)How to verify itExact-lot documentation on request
Research-use-only catalog item supplied for laboratory identification and research purposes. Not for human consumption.
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Need supplies too? Add the Retatrutide Starter Kitplus bacteriostatic water, syringes, and alcohol pads for just +$30View →Description
Retatrutide is a research peptide studied for its activity at three metabolic signaling receptors: GLP-1, GIP and glucagon. It is used in laboratory work to compare single, dual and triple receptor activity in metabolic research models. Supplied as a lyophilized powder, strictly for laboratory research and analytical use.
Intended use · In-vitro laboratory research only. Not for human or animal consumption, and not for clinical, diagnostic, cosmetic or personal use.
N° 002 · How It Works
How Retatrutide works.
Retatrutide acts on three hormone receptors at once: GLP-1, GIP and glucagon. Researchers call this a triple agonist, to separate it from compounds that hit only one or two of those targets. GLP-1 and GIP are incretin receptors, involved in insulin release and appetite signalling. The glucagon receptor adds a third pathway, tied to how the liver and fat tissue use energy. A fatty acid chain on the molecule makes it last longer. It was first described in a 2022 paper in Cell Metabolism, and its metabolic effects were measured in two phase 2 trials in 2023.
Studies referenced
- 1.Coskun T, Urva S, Roell WC, et al. (2022). LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. PubMed 35985340 · doi:10.1016/j.cmet.2022.07.013
- 2.Jastreboff AM, Kaplan LM, Frías JP, et al. (2023). Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med. PubMed 37366315 · doi:10.1056/NEJMoa2301972
- 3.Rosenstock J, Frias J, Jastreboff AM, et al. (2023). Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. Lancet. PubMed 37385280 · doi:10.1016/S0140-6736(23)01053-X
- 4.Urva S, O'Farrell L, Du Y, et al. (2023). The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying. Diabetes Obes Metab. PubMed 37311727 · doi:10.1111/dom.15167
These are the studies behind the summary above. They describe laboratory, animal or clinical research, not this product.
N° 003 · Research Areas
What researchers study Retatrutide for.
Areas where Retatrutide shows up in published research. Listed for context only. We don't give dosing or human-use guidance.
- 01Obesity and body-weight research models
- 02Blood sugar and type 2 diabetes models
- 03Liver fat (MASH/NASH) studies
- 04Energy use and metabolism studies
N° 004 · Specifications
Product specifications.
The molecular details for this compound.
Molecular Spec Sheet
Edition · 2026
- Catalog ID
- SP-RETATRUTIDE-10
- Purity
- 99.705% (HPLC)
- Molecular Weight
- ≈ 4 731 Da
- Empirical Formula
- C221H343N53O68
- CAS Number
- 2381089-83-2
- Sequence Note
- 39-residue synthetic peptide bearing a C20 diacid lipid moiety
- Storage
- 2 to 8°C, protect from light
- Intended Use
- Laboratory research only
N° 005 · Lab Handling
Reconstitution & storage notes.
- 01Reconstitute in bacteriostatic or sterile water for in-vitro reference work
- 02Once reconstituted, aliquot to minimise freeze and thaw cycles
- 03Store lyophilized vial at 2 to 8°C; long-term storage at −20°C
All products are intended strictly for laboratory research use only. Not for human consumption. Not for medical, diagnostic, therapeutic, veterinary, or household use. Product information is provided for research identification and catalog purposes only.
N° 006 · Related
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Researcher Reviews
★★★★★ 5.0 · 1 review
This is an excellent product. The purest highest quality peptide I have come across.
Jacob M